Family history is a risk factor for heart disease, as there have been a number of genes that have been implicated in heart disease. Other associated conditions with CAD are rheumatologic conditions or autoimmune conditions, which include, for example, Lupus or Rheumatoid Arthritis, which had been shown to have a higher rate of coronary artery disease. Depression as well - while the pathophysiology isn't really well known - has been associated with a higher risk of CAD as well. In addition, people with a family history of heart disease are also at an increased risk of having heart disease themselves, as there have been a number of genes implicated in ischemic heart disease.
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